The use of extracorporeal membrane oxygenation (ECMO) support for cardiac and
respiratory failure has increased in recent years. Improvements in ECMO oxygenator and …

Background Extracorporeal membrane oxygenation (ECMO) has been used in clinical
medicine for 40 years but remains controversial therapy, particularly in adult patients with …

Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

Rationale: Recent pediatric studies suggest a survival benefit exists for higher-volume
extracorporeal membrane oxygenation (ECMO) centers. Objectives: To determine if higher …

Background Severe acute respiratory failure in adults causes high mortality despite
improvements in ventilation techniques and other treatments (eg, steroids, prone …

READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton,
Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society …

Interpreting statistical data as evidence, Statistical Evidence: A Likelihood Paradigm focuses
on the law of likelihood, fundamental to solving many of the problems associated with …

Why study the theory of experiment design? Although it can be useful to know about special
designs for specific purposes, experience suggests that a particular design can rarely be …

Background Inhaled nitric oxide improves gas exchange in neonates, but the efficacy of low-
dose inhaled nitric oxide in reducing the need for extracorporeal membrane oxygenation …

Objectives. In the era before widespread use of inhaled nitric oxide, to determine the
prevalence of persistent pulmonary hypertension (PPHN) in a multicenter cohort …