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Oxidative stress and neurodegeneration in animal models of seizures and epilepsy
K Łukawski, SJ Czuczwar - Antioxidants, 2023 - mdpi.com
Free radicals are generated in the brain, as well as in other organs, and their production is
proportional to the brain activity. Due to its low antioxidant capacity, the brain is particularly …
proportional to the brain activity. Due to its low antioxidant capacity, the brain is particularly …
Cerebral plasticity: Windows of opportunity in the develo** brain
Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …
nervous system (CNS) to undergo maturation, change structurally and functionally in …
Prevention of epilepsy in infants with tuberous sclerosis complex in the EPISTOP trial
Objective Epilepsy develops in 70 to 90% of children with tuberous sclerosis complex (TSC)
and is often resistant to medication. Recently, the concept of preventive antiepileptic …
and is often resistant to medication. Recently, the concept of preventive antiepileptic …
Epileptogenesis
Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …
Hippocampal sclerosis in epilepsy: a neuropathology review
M Thom - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …
MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy
Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …
New avenues for anti-epileptic drug discovery and development
Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …
fail to control seizures in 20–30% of patients. However, our understanding of the …
Single-target versus multi-target drugs versus combinations of drugs with multiple targets: Preclinical and clinical evidence for the treatment or prevention of epilepsy
Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …
Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development
Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
Epilepsy is a prevalent neurological disorder associated with significant morbidity and
mortality, but the only available drug therapies target its symptoms rather than the underlying …
mortality, but the only available drug therapies target its symptoms rather than the underlying …