Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity

PV Markov, A Katzourakis, NI Stilianakis - Nature Reviews Microbiology, 2022 - nature.com
The comparatively milder infections with the Omicron variant and higher levels of population
immunity have raised hopes for a weakening of the pandemic. We argue that the lower …

Fitness, growth and transmissibility of SARS-CoV-2 genetic variants

E Volz - Nature Reviews Genetics, 2023 - nature.com
The massive scale of the global SARS-CoV-2 sequencing effort created new opportunities
and challenges for understanding SARS-CoV-2 evolution. Rapid detection and assessment …

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

J Zhang, T **ao, Y Cai, CL Lavine, H Peng, H Zhu… - Science, 2021 - science.org
The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
outcompeted previously prevalent variants and become a dominant strain worldwide. We …

Retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic

S Moore, EM Hill, L Dyson, MJ Tildesley, MJ Keeling - Nature Medicine, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused
considerable morbidity and mortality worldwide. The protection provided by vaccines and …

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

H Tegally, JE San, M Cotten, M Moir, B Tegomoh… - Science, 2022 - science.org
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing
in Africa over the past year has led to a major increase in the number of sequences that …

The origins and molecular evolution of SARS-CoV-2 lineage B. 1.1. 7 in the UK

V Hill, L Du Plessis, TP Peacock, D Aggarwal… - Virus …, 2022 - academic.oup.com
The first SARS-CoV-2 variant of concern (VOC) to be designated was lineage B. 1.1. 7, later
labelled by the World Health Organization as Alpha. Originating in early autumn but …

Context-specific emergence and growth of the SARS-CoV-2 Delta variant

JT McCrone, V Hill, S Bajaj, RE Pena, BC Lambert… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Delta (Pango lineage B. 1.617. 2) variant of concern spread
globally, causing resurgences of COVID-19 worldwide,. The emergence of the Delta variant …

The emergence of SARS-CoV-2 variants of concern is driven by acceleration of the substitution rate

JH Tay, AF Porter, W Wirth… - Molecular Biology and …, 2022 - academic.oup.com
The ongoing SARS-CoV-2 pandemic has seen an unprecedented amount of rapidly
generated genome data. These data have revealed the emergence of lineages with …

Emergence of SARS-CoV-2 variants in the world: how could this happen?

A Parra-Lucares, P Segura, V Rojas, C Pumarino… - Life, 2022 - mdpi.com
The COVID-19 pandemic has had a significant global impact, with more than 280,000,000
people infected and 5,400,000 deaths. The use of personal protective equipment and the …

Intrinsic D614G and P681R/H mutations in SARS-CoV-2 VoCs Alpha, Delta, Omicron and viruses with D614G plus key signature mutations in spike protein alters …

R Khatri, G Siddqui, S Sadhu, V Maithil… - Medical Microbiology …, 2023 - Springer
The SARS-CoV-2 virus has been rapidly evolving over the time and the genetic variation
has led to the generation of Variants of Concerns (VoC), which have shown increased …