In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Mechanical environment has a crucial role in our organism at the different levels, ranging
from cells to tissues and our own organs. This regulatory role is especially relevant for …

It is well-established that cyclic, but not static, mechanical loading has anabolic effects on
bone. However, the function describing the relationship between the loading frequency and …

In this paper we numerically simulate the phenomenon of bone growth in bone defects as
driven by external mechanical excitation. Bone growth is accounted for through a continuum …

Osteoblast migration is a crucial process in bone regeneration, which is strongly regulated
by interstitial fluid flow. However, the exact role that such flow exerts on osteoblast migration …

Bone healing is a complex process with an increased metabolic activity and consequently
high demand for oxygen. In the hematoma phase, inflammatory cells and mesenchymal …

Combining contributions from engineering and medicine, we highlight the biomechanical
turning points in the historical evolution of the intramedullary nailing stabilization technique …

Fracture healing is a very complex physiological process involving multiple events at
different temporal and spatial scales, such as cell migration and tissue differentiation, in …

After fractures, bone can experience different potential outcomes: successful bone
consolidation, non-union and bone failure. Although, there are a lot of factors that influence …

Osteocytes, the major type of bone cells embedded in the bone matrix and surrounded by
the lacunar and canalicular system, can serve as biomechanosensors and …