Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Abstract Background Fusobacterium nucleatum (Fn) acts as a procarcinogenic bacterium in
colorectal carcinoma (CRC) by regulating the inflammatory tumor microenvironment (TME) …

As the main protein components of chromatin, histones play central roles in gene regulation
as spools of winding DNA. Histones are subject to various modifications, including …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Citrullination is the post-translational conversion of an arginine residue within a protein to
the non-coded amino acid citrulline. This modification leads to the loss of a positive charge …

Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

Human proteins are subjected to more than 200 known post-translational modifications
(PTMs)(eg, phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation …

Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally
encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in …