BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Neurons are highly polarized cells with an elongated axon that extends far away from the
cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of …

Mutations in the microtubule-associated motor protein KIF1A lead to severe neurological
conditions known as KIF1A-associated neurological disorders (KAND). Despite insights into …

Cortical/cerebral visual impairment (CVI) is the most frequent cause of pediatric visual
impairment in developed countries and is increasing in prevalence in develo** nations …

Variants in the KIF1A gene can cause autosomal recessive spastic paraplegia 30,
autosomal recessive hereditary sensory neuropathy, or autosomal (de novo) dominant …

KIF1A is a kinesin family motor involved in the axonal transport of synaptic vesicle
precursors (SVPs) along microtubules (MTs). In humans, more than 10 point mutations in …

Neuronal function depends on axonal transport by kinesin superfamily proteins (KIFs).
KIF1A is the molecular motor that transports synaptic vesicle precursors, synaptic vesicles …

KIF1A-associated neurological disorder (KAND) encompasses a group of rare
neurodegenerative conditions caused by variants in KIF1A, a gene that encodes an …

BORC is a multisubunit complex previously shown to promote coupling of mammalian
lysosomes and C. elegans synaptic vesicle (SV) precursors (SVPs) to kinesins for …

KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in
axons. Cargo binding stimulates the dimerization of KIF1A molecules to induce processive …