Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Intense multidisciplinary research has provided detailed knowledge of the molecular
pathogenesis of Alzheimer disease (AD). This knowledge has been translated into new …
pathogenesis of Alzheimer disease (AD). This knowledge has been translated into new …
Inflammation in Alzheimer disease—a brief review of the basic science and clinical literature
T Wyss-Coray, J Rogers - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Biochemical and neuropathological studies of brains from individuals with Alzheimer
disease (AD) provide clear evidence for an activation of inflammatory pathways, and long …
disease (AD) provide clear evidence for an activation of inflammatory pathways, and long …
Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline
The neuropathological confirmation of amyloid-β (Aβ) plaques and tau neurofibrillary
tangles (NFT) remains the gold standard for a definitive diagnosis of Alzheimer's disease …
tangles (NFT) remains the gold standard for a definitive diagnosis of Alzheimer's disease …
Plasma phospholipids identify antecedent memory impairment in older adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
Nanopore sequencing of DNA-barcoded probes for highly multiplexed detection of microRNA, proteins and small biomarkers
C Koch, B Reilly-O'Donnell, R Gutierrez… - Nature …, 2023 - nature.com
There is an unmet need to develop low-cost, rapid and highly multiplexed diagnostic
technology platforms for quantitatively detecting blood biomarkers to advance clinical …
technology platforms for quantitatively detecting blood biomarkers to advance clinical …
Plasma proteomic profiles predict future dementia in healthy adults
Y Guo, J You, Y Zhang, WS Liu, YY Huang, YR Zhang… - Nature Aging, 2024 - nature.com
The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology
Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …
At the interface of sensory and motor dysfunctions and Alzheimer's disease
Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
Alzheimer's disease affects millions of people around the world. Currently, there are no
treatments that prevent or slow the disease. Like other neurodegenerative diseases …
treatments that prevent or slow the disease. Like other neurodegenerative diseases …
Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer's disease
A deeper understanding of the molecular processes underlying late-onset Alzheimer's
disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput …
disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput …