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Single-cell proteomics
The inability to make broad, minimally biased measurements of a cell's proteome stands as
a major bottleneck for understanding how gene expression translates into cellular …
a major bottleneck for understanding how gene expression translates into cellular …
Single-cell analysis targeting the proteome
The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …
provides a strong rationale for a need for analytical methods that enable analysis at the …
Top-down models in biology: explanation and control of complex living systems above the molecular level
It is widely assumed in developmental biology and bioengineering that optimal
understanding and control of complex living systems follows from models of molecular …
understanding and control of complex living systems follows from models of molecular …
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
The determination of individual cell trajectories through a high-dimensional cell-state space
is an outstanding challenge for understanding biological changes ranging from cellular …
is an outstanding challenge for understanding biological changes ranging from cellular …
The intriguing landscape of single‐cell protein analysis
H **e, X Ding - Advanced Science, 2022 - Wiley Online Library
Profiling protein expression at single‐cell resolution is essential for fundamental biological
research (such as cell differentiation and tumor microenvironmental examination) and …
research (such as cell differentiation and tumor microenvironmental examination) and …
Microfluidics towards single cell resolution protein analysis
Single cell analysis has aroused great interest with its remarkable ability to investigate cell-
to-cell heterogeneity in large populations. However, probing protein information at single …
to-cell heterogeneity in large populations. However, probing protein information at single …
Computational quantification and characterization of independently evolving cellular subpopulations within tumors is critical to inhibit anti-cancer therapy resistance
H Alkhatib, AM Rubinstein, S Vasudevan… - Genome medicine, 2022 - Springer
Background Drug resistance continues to be a major limiting factor across diverse anti-
cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in …
cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in …
Single cell proteomics in biomedicine: High‐dimensional data acquisition, visualization, and analysis
New insights on cellular heterogeneity in the last decade provoke the development of a
variety of single cell omics tools at a lightning pace. The resultant high‐dimensional single …
variety of single cell omics tools at a lightning pace. The resultant high‐dimensional single …
Solute-mediated interactions between active droplets
Concentration gradients play a critical role in embryogenesis, bacterial locomotion, as well
as the motility of active particles. Particles develop concentration profiles around them by …
as the motility of active particles. Particles develop concentration profiles around them by …
Profiling the origin, dynamics, and function of traction force in B cell activation
B lymphocytes use B cell receptors (BCRs) to recognize membrane-bound antigens to
further initiate cell spreading and contraction responses during B cell activation. We …
further initiate cell spreading and contraction responses during B cell activation. We …