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Reconsidering the role of mitochondria in aging
Background: Mitochondrial dysfunction has long been considered a major contributor to
aging and age-related diseases. Harman's Mitochondrial Free Radical Theory of Aging …
aging and age-related diseases. Harman's Mitochondrial Free Radical Theory of Aging …
Towards a unified mechanistic theory of aging
A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …
are highly conserved during evolution from yeast and invertebrates to mammals. Many …
The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity
The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …
[HTML][HTML] Mitochondrial dysfunction in cardiac aging
Cardiovascular diseases are the leading cause of death in most developed nations. While it
has received the least public attention, aging is the dominant risk factor for develo** …
has received the least public attention, aging is the dominant risk factor for develo** …
[HTML][HTML] Mitochondrial effects of common cardiovascular medications: The good, the bad and the mixed
Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …
integration of several physiological processes, such as ATP generation via oxidative …
[HTML][HTML] Impact of aldosterone on the failing myocardium: insights from mitochondria and adrenergic receptors signaling and function
The mineralocorticoid aldosterone regulates electrolyte and blood volume homeostasis, but
it also adversely modulates the structure and function of the chronically failing heart, through …
it also adversely modulates the structure and function of the chronically failing heart, through …
Impaired cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with Barth syndrome
Barth syndrome (BTHS) is an X‐linked condition characterized by altered cardiolipin
metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal …
metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal …
Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction
It has been described that dietary cysteine reverses many of the beneficial changes induced
by methionine restriction in aging rodents. In this investigation male Wistar rats were …
by methionine restriction in aging rodents. In this investigation male Wistar rats were …
[HTML][HTML] Targeting adrenergic receptors in metabolic therapies for heart failure
DM Perez - International Journal of Molecular Sciences, 2021 - mdpi.com
The heart has a reduced capacity to generate sufficient energy when failing, resulting in an
energy-starved condition with diminished functions. Studies have identified numerous …
energy-starved condition with diminished functions. Studies have identified numerous …
Lifelong docosahexaenoic acid intervention ameliorates aging in the telomere-DNA-mitochondria axis in telomerase-deficient mice
S Wu, Y Wu, J Chen, P Zhuang, Y Zhang… - The Journal of Nutritional …, 2023 - Elsevier
The health benefits of n-3 polyunsaturated fatty acids (PUFAs) in multiple age-related
diseases are associated with telomere length. Telomerase is intimately related to …
diseases are associated with telomere length. Telomerase is intimately related to …