Roles of Werner syndrome protein in protection of genome integrity
Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated
in the maintenance of genome stability. The conserved RecQ family also includes RecQ1 …
in the maintenance of genome stability. The conserved RecQ family also includes RecQ1 …
DNA Repair in Drosophila: Mutagens, Models, and Missing Genes
The numerous processes that damage DNA are counterbalanced by a complex network of
repair pathways that, collectively, can mend diverse types of damage. Insights into these …
repair pathways that, collectively, can mend diverse types of damage. Insights into these …
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes
DNA repair declines with age and correlates with longevity in many animal species. In this
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases
Aging is a natural and unavoidable part of life. However, aging is also the primary driver of
the dominant human diseases, such as cardiovascular disease, cancer, and …
the dominant human diseases, such as cardiovascular disease, cancer, and …
[HTML][HTML] Anti-aging effect of brown black wolfberry on Drosophila melanogaster and D-galactose-induced aging mice
J Zhang, X Liu, J Pan, Q Zhao, Y Li, W Gao… - Journal of Functional …, 2020 - Elsevier
Aging is a global challenge. Many studies reported that the accumulation of ROS and
oxidative stress could be the most important causative factors for aging. Phenolic …
oxidative stress could be the most important causative factors for aging. Phenolic …
Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome
E Sember, R Chennakesavula, B Beard… - G3: Genes …, 2024 - academic.oup.com
Werner syndrome (WS) is a rare genetic disease in humans, caused by mutations in the
WRN gene that encodes a protein containing helicase and exonuclease domains. WS is …
WRN gene that encodes a protein containing helicase and exonuclease domains. WS is …
Animal and human models to understand ageing
Human ageing is the gradual decline in organ and tissue function with increasing
chronological time, leading eventually to loss of function and death. To study the processes …
chronological time, leading eventually to loss of function and death. To study the processes …
The role of DNA exonucleases in protecting genome stability and their impact on ageing
Exonucleases are key enzymes involved in many aspects of cellular metabolism and
maintenance and are essential to genome stability, acting to cleave DNA from free ends …
maintenance and are essential to genome stability, acting to cleave DNA from free ends …
Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine …
Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular
level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID …
level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID …
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability
DNA helicases are ubiquitous enzymes that catalyze unwinding of duplex DNA and function
in all metabolic processes in which access to single-stranded DNA is required, including …
in all metabolic processes in which access to single-stranded DNA is required, including …