Diabetic neuropathy: cellular mechanisms as therapeutic targets

AM Vincent, BC Callaghan, AL Smith… - Nature Reviews …, 2011 - nature.com
In patients with diabetes, nerve injury is a common complication that leads to chronic pain,
numbness and substantial loss of quality of life. Good glycemic control can decrease the …

Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders

S Agarwal, A Yadav, RK Chaturvedi - Biochemical and biophysical …, 2017 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to
be a promising therapeutic target for several neurodegenerative disorders, which includes …

Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats

J Cacho, J Sevillano, J de Castro… - American journal …, 2008 - journals.physiology.org
Insulin resistance plays a role in the pathogenesis of diabetes, including gestational
diabetes. The glucose clamp is considered the gold standard for determining in vivo insulin …

Gut microbiota and diet in patients with different glucose tolerance

L Egshatyan, D Kashtanova, A Popenko… - Endocrine …, 2016 - ec.bioscientifica.com
Elevated C-terminal fibroblast growth factor 23 (C-FGF23) concentrations have been
reported in Gambian children with and without putative Ca-deficiency rickets. The aims of …

Retinoid X receptors: X-ploring their (patho) physiological functions

A Szanto, V Narkar, Q Shen, IP Uray… - Cell Death & …, 2004 - nature.com
Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that
regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as …

A review of rodent models of type 2 diabetic skeletal fragility

RJ Fajardo, L Karim, VI Calley… - Journal of Bone and …, 2014 - academic.oup.com
Evidence indicating that adult type 2 diabetes (T2D) is associated with increased fracture
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …

PPARα governs glycerol metabolism

D Patsouris, S Mandard, PJ Voshol, P Escher… - The Journal of clinical …, 2004 - jci.org
Glycerol, a product of adipose tissue lipolysis, is an important substrate for hepatic glucose
synthesis. However, little is known about the regulation of hepatic glycerol metabolism. Here …

[HTML][HTML] Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice

T Murase, S Haramizu… - American Journal …, 2005 - journals.physiology.org
Green tea contains a high level of polyphenolic compounds known as catechins. We
investigated the effects of green tea extract (GTE), which is rich in catechins, on endurance …

[HTML][HTML] A high-whey-protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in wistar rats

DP Belobrajdic, GH McIntosh, JA Owens - The Journal of nutrition, 2004 - Elsevier
A high-protein diet can reduce body weight and increase insulin sensitivity, but whether the
type of dietary protein affects these outcomes is unknown. We hypothesized that feeding …

Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor α and γ and reduce insulin resistance

H Yajima, E Ikeshima, M Shiraki, T Kanaya… - Journal of Biological …, 2004 - jbc.org
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that
regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of fibrate drugs …