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Diabetic neuropathy: cellular mechanisms as therapeutic targets
AM Vincent, BC Callaghan, AL Smith… - Nature Reviews …, 2011 - nature.com
In patients with diabetes, nerve injury is a common complication that leads to chronic pain,
numbness and substantial loss of quality of life. Good glycemic control can decrease the …
numbness and substantial loss of quality of life. Good glycemic control can decrease the …
Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to
be a promising therapeutic target for several neurodegenerative disorders, which includes …
be a promising therapeutic target for several neurodegenerative disorders, which includes …
Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats
J Cacho, J Sevillano, J de Castro… - American journal …, 2008 - journals.physiology.org
Insulin resistance plays a role in the pathogenesis of diabetes, including gestational
diabetes. The glucose clamp is considered the gold standard for determining in vivo insulin …
diabetes. The glucose clamp is considered the gold standard for determining in vivo insulin …
Gut microbiota and diet in patients with different glucose tolerance
L Egshatyan, D Kashtanova, A Popenko… - Endocrine …, 2016 - ec.bioscientifica.com
Elevated C-terminal fibroblast growth factor 23 (C-FGF23) concentrations have been
reported in Gambian children with and without putative Ca-deficiency rickets. The aims of …
reported in Gambian children with and without putative Ca-deficiency rickets. The aims of …
Retinoid X receptors: X-ploring their (patho) physiological functions
Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that
regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as …
regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as …
A review of rodent models of type 2 diabetic skeletal fragility
Evidence indicating that adult type 2 diabetes (T2D) is associated with increased fracture
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …
PPARα governs glycerol metabolism
Glycerol, a product of adipose tissue lipolysis, is an important substrate for hepatic glucose
synthesis. However, little is known about the regulation of hepatic glycerol metabolism. Here …
synthesis. However, little is known about the regulation of hepatic glycerol metabolism. Here …
[HTML][HTML] Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice
T Murase, S Haramizu… - American Journal …, 2005 - journals.physiology.org
Green tea contains a high level of polyphenolic compounds known as catechins. We
investigated the effects of green tea extract (GTE), which is rich in catechins, on endurance …
investigated the effects of green tea extract (GTE), which is rich in catechins, on endurance …
[HTML][HTML] A high-whey-protein diet reduces body weight gain and alters insulin sensitivity relative to red meat in wistar rats
A high-protein diet can reduce body weight and increase insulin sensitivity, but whether the
type of dietary protein affects these outcomes is unknown. We hypothesized that feeding …
type of dietary protein affects these outcomes is unknown. We hypothesized that feeding …
Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor α and γ and reduce insulin resistance
H Yajima, E Ikeshima, M Shiraki, T Kanaya… - Journal of Biological …, 2004 - jbc.org
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that
regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of fibrate drugs …
regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of fibrate drugs …