Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Cancer immunotherapy has transformed traditional treatments, with immune checkpoint
blockade being particularly prominent. However, immunotherapy has minimal benefit for …

As one of the four major means of cancer treatment including surgery, radiotherapy (RT),
chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical …

Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Glioblastoma (GBM) is the most malignant of astrocytomas mainly involving the cerebral
hemispheres and the cerebral cortex. It is one of the fatal and refractory solid tumors, with a …

Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the
drug delivery. Here, we demonstrate that NSCs effectively transport antisense …

Background Myeloid-derived suppressor cells (MDSCs) represent a negative prognostic
factor in malignant melanoma. These cells are generated under chronic inflammatory …

Signal transducer and activator of transcription 3 (STAT3) plays an important role in the
occurrence and progression of tumors, leading to resistance and poor prognosis. Activation …

Myeloid-derived suppressor cells (MDSCs) significantly hinder the immune response to
tumor radiotherapy (RT) because of their massive accumulation in tumors after RT, resulting …

Eradication of head-and-neck (H&N) tumors is very difficult and challenging because of the
characteristic feature of frequent recurrence and the difficulty in killing cancer stem cells …