Tumor hypoxia: From basic knowledge to therapeutic implications
Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …
Hypoxia-driven effects in cancer: characterization, mechanisms, and therapeutic implications
Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …
cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in …
USP28 facilitates pancreatic cancer progression through activation of Wnt/β-catenin pathway via stabilising FOXM1
L Chen, Z Xu, Q Li, Q Feng, C Zheng, Y Du… - Cell death & …, 2021 - nature.com
Ubiquitination is an important post-translational modification that can be reversed by a family
of enzymes called deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 28 …
of enzymes called deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 28 …
The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic microenvironment
Alterations in protein ubiquitination and hypoxia-inducible factor (HIF) signaling both
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …
USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer
Clear cell renal cell carcinoma (ccRCC) is characterized by the loss of tumor suppressor
Von Hippel Lindau (VHL) function. VHL is the component of an E3 ligase complex that …
Von Hippel Lindau (VHL) function. VHL is the component of an E3 ligase complex that …
USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression
R Tu, J Ma, Y Chen, Y Kang, D Ren, Z Cai… - Cell Death & …, 2024 - nature.com
Clear cell renal cell carcinoma (ccRCC) is characterized by Von Hippel Lindau (VHL) gene
loss of function mutation, which leads to the accumulation of hypoxia-inducible factor 2α …
loss of function mutation, which leads to the accumulation of hypoxia-inducible factor 2α …
USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α
W Huang, X Liu, Y Zhang, M Deng, G Li… - Journal of Cellular …, 2022 - Wiley Online Library
Hypoxia‐inducible factor 2α (HIF2α) plays a pivotal role in breast tumor growth and
metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly …
metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly …
Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response
The ubiquitination and proteasome-mediated degradation of Hypoxia Inducible Factors
(HIFs) is central to metazoan oxygen-sensing, but the involvement of deubiquitinating …
(HIFs) is central to metazoan oxygen-sensing, but the involvement of deubiquitinating …
OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation
X Liu, H Deng, J Tang, Z Wang, C Zhu, X Cai… - Cell Death & …, 2022 - nature.com
As a main regulator of cellular responses to hypoxia, the protein stability of hypoxia-
inducible factor (HIF)-1α is strictly controlled by oxygen tension dependent of PHDs …
inducible factor (HIF)-1α is strictly controlled by oxygen tension dependent of PHDs …
HIF2 inactivation and tumor suppression with a tumor-directed RNA-silencing drug in mice and humans
Y Ma, A Joyce, O Brandenburg, F Saatchi… - Clinical Cancer …, 2022 - AACR
Purpose: HIF2α is a key driver of kidney cancer. Using a belzutifan analogue (PT2399), we
previously showed in tumorgrafts (TG) that∼ 50% of clear cell renal cell carcinomas …
previously showed in tumorgrafts (TG) that∼ 50% of clear cell renal cell carcinomas …