Iron in neurodegeneration–cause or consequence?
A Ndayisaba, C Kaindlstorfer… - Frontiers in neuroscience, 2019 - frontiersin.org
Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …
Hypoxia, oxidative stress, and inflammation: three faces of neurodegenerative diseases
A Merelli, M Repetto, A Lazarowski… - Journal of Alzheimer's …, 2021 - content.iospress.com
The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …
Iron and Alzheimer's disease: an update on emerging mechanisms
Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …
However, iron's biological utility as an effective redox cycling metal also endows it with the …
Reactive oxygen species: Physiological and physiopathological effects on synaptic plasticity: Supplementary issue: Brain plasticity and repair
TF Beckhauser, J Francis-Oliveira… - Journal of …, 2016 - journals.sagepub.com
In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …
A delicate balance: Iron metabolism and diseases of the brain
Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …
cellular processes including neurotransmitter synthesis, myelination of neurons, and …
Iron imbalance in neurodegeneration
Iron is an essential element for the development and functionality of the brain, and
anomalies in its distribution and concentration in brain tissue have been found to be …
anomalies in its distribution and concentration in brain tissue have been found to be …
Inflammation alters the expression of DMT 1, FPN 1 and hepcidin, and it causes iron accumulation in central nervous system cells
P Urrutia, P Aguirre, A Esparza, V Tapia… - Journal of …, 2013 - Wiley Online Library
Inflammation and iron accumulation are present in a variety of neurodegenerative diseases
that include Alzheimer's disease and Parkinson's disease. The study of the putative …
that include Alzheimer's disease and Parkinson's disease. The study of the putative …
Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress
Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
The calcium–iron connection in ferroptosis-mediated neuronal death
Iron, through its participation in oxidation/reduction processes, is essential for the
physiological function of biological systems. In the brain, iron is involved in the development …
physiological function of biological systems. In the brain, iron is involved in the development …
The role of metallobiology and amyloid‐β peptides in Alzheimer's disease
J. Neurochem.(2012) 120 (Suppl. 1), 149–166. Abstract The biggest risk factor for
Alzheimer's disease is the process of ageing, but the mechanisms that lead to the …
Alzheimer's disease is the process of ageing, but the mechanisms that lead to the …