Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …

Proton detection developed in the last 20 years as the method of choice to study
biomolecules in the solid state. In perdeuterated proteins, proton dipolar interactions are …

Conventional understanding of how enzymes function strongly emphasizes the role of
structure. However, increasing evidence clearly indicates that enzymes do not remain fixed …

Conspectus Solid-state nuclear magnetic resonance (ssNMR) is a spectroscopic technique
that is used for characterization of molecular properties in the solid phase at atomic …

The C-terminally truncated Y145Stop variant of prion protein (PrP23-144), which is
associated with heritable PrP cerebral amyloid angiopathy in humans and also capable of …

In this chapter, we discuss recent advances in solid-state magic angle spinning (MAS) NMR
spectroscopy of microcrystalline proteins. We review approaches for isotopic labelling and …

Uropathogenic Escherichia coli invades and colonizes hosts by attaching to cells using
adhesive pili on the bacterial surface. Although many biophysical techniques have been …

In this report we present site-specific measurements of amide hydrogen-deuterium
exchange rates in a protein in the solid state phase by MAS NMR. Employing …

Proton detection has revolutionized the field of solid-state NMR recently. Here we
comprehensively explain the general aspects of this methodology for protein targets …

The design of a novel drug is a creative act. The difference between a researcher and an
artist, besides the pursuit of a particular goal, is that his/her creativity is based on scientific …