The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Teleost muscle first arises in early embryonic life and its development is driven by molecules
present in the egg yolk and modulated by environmental stimuli including temperature and …

Covalent modifications of histones are central to the regulation of chromatin dynamics, and,
therefore, many biological processes involving chromatin, such as replication, repair …

Background Disrupting the balance of histone lysine methylation alters the expression of
genes involved in tumorigenesis including proto-oncogenes and cell cycle regulators …

Little is known about the genetic basis of convergent traits that originate repeatedly over
broad taxonomic scales. The myogenic electric organ has evolved six times in fishes to …

The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein
complex with the actin and myosin filaments at its core. Assembling the sarcomere …

Regulation of multipotent cardiac progenitor cell (CPC) expansion and subsequent
differentiation into cardiomyocytes, smooth muscle or endothelial cells is a fundamental …

SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-
DEAF1) domain-containing proteins (SMYD) have been found to methylate a variety of …

The cardiovascular system is broadly composed of the heart, which pumps blood, and the
blood vessels, which carry blood to and from tissues of the body. Heart malformations are …

Epigenetic control mechanisms determine active and silenced regions of the genome. It is
known that the Polycomb Repressive Complex 2 (PRC2) and the Trithorax group/Mixed …