Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs).
While the field of lipophagy research is relatively young, an expansion of research in this …

Abnormal conditions during early development adversely affect later health. We investigated
whether maternal exercise could protect offspring from adverse effects of a maternal high-fat …

Background: The Notch signaling pathway is implicated in a broad range of developmental
processes, including cell fate decisions. This study was designed to determine the role of …

Insulin is a critical hormone that promotes energy storage in various tissues, as well as
anabolic functions. Insulin resistance significantly reduces these responses, resulting in …

Autophagy pathways are involved in the pathogenesis of some obesity related health
problems. As obesity is a nutrient sufficiency condition, autophagy process can be altered in …

Autophagy, a process of cellular self-digestion, delivers intracellular components including
superfluous and dysfunctional proteins and organelles to the lysosome for degradation and …

Metabolic syndrome (MetS) is a complex, emerging epidemic which disrupts the metabolic
homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While …

Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the
production of the energy load needed at critical times during development and in response …

White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels
in response to nutritional cues. WAT expands to store excess energy by increasing …