Primary aldosteronism is a common cause of secondary hypertension associated with
excess cardiovascular morbidities. Primary aldosteronism is underdiagnosed because it …

Primary aldosteronism is considered the commonest cause of secondary hypertension. In
affected individuals, aldosterone is produced in an at least partially autonomous fashion in …

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of
ion channels or transporters. However, their frequency in aldosterone-producing cell …

The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …

The adrenal glands are paired endocrine organs that produce steroid hormones and
catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal …

Female bias is highly prevalent in conditions such as adrenal cortex hyperplasia and
neoplasia, but the reasons behind this phenomenon are poorly understood. In this study, we …

Resident progenitor and/or stem cell populations in the adult adrenal cortex enable cortical
cells to undergo homeostatic renewal and regeneration after injury. Renewal occurs …

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited
therapeutic options. The lack of mouse models that recapitulate the genetics of ACC has …

Primary aldosteronism (PA) can be sporadic or familial and classified into unilateral and
bilateral forms. Sporadic PA predominates with excessive aldosterone production usually …

In humans, reticularis cells of the adrenal cortex fuel the production of androgen steroids,
constituting the driver of numerous morphological changes during childhood. These steps …