The neuroscience of drug reward and addiction
Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …
Targeting glutamate uptake to treat alcohol use disorders
Alcoholism is a serious public health concern that is characterized by the development of
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …
Essential role of mesolimbic brain-derived neurotrophic factor in chronic social stress–induced depressive behaviors
Background Previous work has shown that chronic social defeat stress (CSDS) induces
increased phasic firing of ventral tegmental area (VTA) dopamine (DA) neurons that project …
increased phasic firing of ventral tegmental area (VTA) dopamine (DA) neurons that project …
Cortical cholinergic signaling controls the detection of cues
The cortical cholinergic input system has been described as a neuromodulator system that
influences broadly defined behavioral and brain states. The discovery of phasic, trial-based …
influences broadly defined behavioral and brain states. The discovery of phasic, trial-based …
Dopamine receptors: is it possible to become a therapeutic target for depression?
F Zhao, Z Cheng, J Piao, R Cui, B Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Dopamine and its receptors are currently recognized targets for the treatment of several
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …
Circadian clock genes: effects on dopamine, reward and addiction
Addiction is a widespread public health issue with social and economic ramifications.
Substance abuse disorders are often accompanied by disruptions in circadian rhythms …
Substance abuse disorders are often accompanied by disruptions in circadian rhythms …
Distinct neuromodulatory effects of endogenous orexin and dynorphin corelease on projection-defined ventral tegmental dopamine neurons
Dopamine (DA) neurons in the ventral tegmental area (VTA) respond to motivationally
relevant cues, and circuit-specific signaling drives different aspects of motivated behavior …
relevant cues, and circuit-specific signaling drives different aspects of motivated behavior …
Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users
Background Preclinical research has demonstrated a causal relationship between medial
prefrontal cortex activity and cocaine self-administration. As a step towards translating those …
prefrontal cortex activity and cocaine self-administration. As a step towards translating those …
Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI
Dopamine neurons in the ventral tegmental area (VTA) are strongly implicated in cognitive
and affective processing as well as in psychiatric disorders, including schizophrenia …
and affective processing as well as in psychiatric disorders, including schizophrenia …
Midbrain circuit regulation of individual alcohol drinking behaviors in mice
Alcohol-use disorder (AUD) is the most prevalent substance-use disorder worldwide. There
is substantial individual variability in alcohol drinking behaviors in the population, the neural …
is substantial individual variability in alcohol drinking behaviors in the population, the neural …