Calcium-activated potassium (KCa) channels are ubiquitously expressed throughout the
body and are able to regulate membrane potential and intracellular calcium concentrations …

Neuronal signal transmission depends on the frequency, pattern, and timing of spike output,
each of which are shaped by spike afterhyperpolarizations (AHPs). There are classically …

Gene therapy offers a potential alternative to the surgical treatment of epilepsy, which affects
millions of people and is pharmacoresistant in~ 30% of cases. Aimed at reducing the …

Introduction K+ channels are of great interest to epilepsy research as mutations in their
genes are found in humans with inherited epilepsy. At the level of cellular physiology, K+ …

In neocortical layer‐5 pyramidal neurons, the action potential (AP) is generated in the axon
initial segment (AIS) when the membrane potential (Vm) reaches the threshold for activation …

It is well recognized that changes in the extracellular concentration of calcium ions influence
the excitability of neurons, yet what mechanism (s) mediate these effects is still a matter of …

The engineered expression of K+ channels has been proposed as a potential treatment for
epilepsy due to their exceptional ability to hyperpolarize neurons. A number of rodent …

Abstract Ca 2+-activated KCa3. 1 channels are known to contribute to slow
afterhyperpolarization in pyramidal neurons of several brain areas, while Ca 2+-permeable …

Vasoactive intestinal peptide (VIP) is an important component of the suprachiasmatic
nucleus (SCN) which relays circadian information to neuronal populations, including GnRH …

Neurons differentiate mechanical stimuli force and rate to elicit unique functional responses,
driving the need for further tools to generate various mechanical stimuli. Here, cell‐internal …