Propofol is an intravenous agent used commonly for the induction and maintenance of
anesthesia, procedural, and critical care sedation in children. The mechanisms of action on …

Paediatric dose cannot be scaled down directly from an adult using weight (eg, mg/kg). This
results in a dose too small in infants and children because elimination does not change in …

This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects
Modeling (NONMEM) system, the most powerful tool for pharmacokinetic/pharmacodynamic …

Propofol administered in conjunction with an opioid such as remifentanil is used to provide
total intravenous anesthesia for children. Drugs can be given as infusion controlled …

There is a nonlinear relationship between structure and functional processes and the mass
of living organisms. Allometric scaling of body mass provides a theory based method for …

Obesity and morbid obesity are associated with many physiological changes affecting
pharmacokinetics, such as increased blood volume, cardiac output, splanchnic blood flow …

Inhalational anesthesia has dominated the practice of pediatric anesthesia. However, as the
introduction of agents such as propofol, short‐acting opioids, midazolam, and …

Importance Obesity affects nearly one-sixth of US children and results in alterations to body
composition and physiology that can affect drug disposition, possibly leading to therapeutic …

Purpose Clinicians are increasingly likely to have under their care obese children with
diseases requiring pharmacotherapy. Optimal drug dosing for this population is unclear …

Lean body mass is commonly proposed for anesthesia maintenance drug dosing
calculations. However, total body mass used with allometric scaling has been shown to be …