Alzheimer's disease treatment: the search for a breakthrough

AB Reiss, D Muhieddine, B Jacob, M Mesbah… - Medicina, 2023 - mdpi.com
As the search for modalities to cure Alzheimer's disease (AD) has made slow progress,
research has now turned to innovative pathways involving neural and peripheral …

Huntington's disease: complex pathogenesis and therapeutic strategies

H Tong, T Yang, S Xu, X Li, L Liu, G Zhou… - International Journal of …, 2024 - mdpi.com
Huntington's disease (HD) arises from the abnormal expansion of CAG repeats in the
huntingtin gene (HTT), resulting in the production of the mutant huntingtin protein (mHTT) …

[HTML][HTML] Antisense oligonucleotides-based approaches for the treatment of multiple myeloma

M Oprea, M Ionita - International Journal of Biological Macromolecules, 2024 - Elsevier
Multiple myeloma (MM), a hematological malignancy which affects the monoclonal plasma
cells in the bone marrow, is in rising incidence around the world, accounting for …

Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases

W Liang, Y Luo, A Xu, J Chu, W Ji, L Wang, Y Gu… - Biomaterials …, 2024 - pubs.rsc.org
Neurodegenerative disease are devastating diseases that severely affected the health of
people all over the world. RNA therapies have become one of the most promising critical …

New insights into polysaccharide-based nanostructured delivery systems in breast cancer: Possible application of antisense oligonucleotides in breast cancer therapy

F Shayegh, Z Turk, A Fejzullahu, N Zarghami - International Journal of …, 2024 - Elsevier
The lack of more effective therapies for breast cancer has enhanced mortality among breast
cancer patients. Recent efforts have established efficient treatments to reduce breast cancer …

Structure-activity relationship of modified amphiphilic cationic cyclodextrins for enhanced siRNA delivery

A Kont, MCP Mendonça, M Malanga, K Felegyi… - International Journal of …, 2025 - Elsevier
The presence of multiple hydroxyl groups at positions C2, C3 and C6 on the cyclodextrin
(CD) ring structure allows for extensive functionalisation, enabling the development of …

Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies

S Liu, H Li, S **, Y Zhang, T Sun - International Journal of …, 2025 - Taylor & Francis
Given the complexity of the central nervous system (CNS) and the diversity of neurological
conditions, the increasing prevalence of neurological disorders poses a significant …

[HTML][HTML] Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders

Y **ng, B Meng, Q Chen - International Journal of Molecular Sciences, 2024 - mdpi.com
Cyclodextrins (CDs) are ubiquitous excipients, constituted of cyclic glucopyranose units, and
possess a unique dual nature, that of a hydrophobic interior and a hydrophilic exterior. This …

Innovation in nanomedicine: nanocarriers for central nervous system disorders management

MA Waqar, N Mubarak, AM Khan… - … Journal of Polymeric …, 2024 - Taylor & Francis
Abstract Rising prevalence of Central Nervous System (CNS) illnesses poses an issue of
concern for global health, requiring new and innovative treatment approaches. Current …