MAP kinase and pain
Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …
MAPK activation in nociceptive neurons and pain hypersensitivity
K Obata, K Noguchi - Life sciences, 2004 - Elsevier
Extracellular signal-regulated protein kinase (ERK) is a mitogen-activated protein kinase
(MAPK) that mediates intracellular signal transduction in response to a variety of stimuli …
(MAPK) that mediates intracellular signal transduction in response to a variety of stimuli …
Chloride regulation in the pain pathway
Melzack and Wall's Gate Control Theory of Pain laid the theoretical groundwork for a role of
spinal inhibition in endogenous pain control. While the Gate Control Theory was based on …
spinal inhibition in endogenous pain control. While the Gate Control Theory was based on …
Luminal hydrogen sulfide plays a pronociceptive role in mouse colon
M Matsunami, T Tarui, K Mitani, K Nagasawa… - Gut, 2009 - gut.bmj.com
Objective: Given recent evidence that hydrogen sulfide (H2S), a gasotransmitter, promotes
somatic pain through redox modulation of T-type Ca2+ channels, the roles of colonic luminal …
somatic pain through redox modulation of T-type Ca2+ channels, the roles of colonic luminal …
Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) suffer from chronic pain that
severely affects quality of life. Although the underlying pathophysiology is not well …
severely affects quality of life. Although the underlying pathophysiology is not well …
Drug management of visceral pain: concepts from basic research
MP Davis - Pain research and treatment, 2012 - Wiley Online Library
Visceral pain is experienced by 40% of the population, and 28% of cancer patients suffer
from pain arising from intra‐abdominal metastasis or from treatment. Neuroanatomy of …
from pain arising from intra‐abdominal metastasis or from treatment. Neuroanatomy of …
In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons
The persistent increase in pain sensitivity observed after injury, known as hyperalgesia,
depends on synaptic plasticity in the pain pathway, particularly in the spinal cord. Several …
depends on synaptic plasticity in the pain pathway, particularly in the spinal cord. Several …
Understanding the signaling and transmission of visceral nociceptive events
Visceral pain can be considered as part of the defense reactions of the body against harmful
stimuli, particularly of those that im**e on the mucosal lining of hollow organs. It is a …
stimuli, particularly of those that im**e on the mucosal lining of hollow organs. It is a …
Activation of ERK/CREB pathway in spinal cord contributes to chronic constrictive injury‐induced neuropathic pain in rats1
X SONG, J CAO, Y XU, J HE… - Acta Pharmacologica …, 2005 - Wiley Online Library
Aim: To investigate whether activation and translocation of extracellular signal‐regulated
kinase (ERK) is involved in the induction and maintenance of neuropathic pain, and effects …
kinase (ERK) is involved in the induction and maintenance of neuropathic pain, and effects …
Neurotrophins in bladder function: what do we know and where do we go from here?
CD Cruz - Neurourology and urodynamics, 2014 - Wiley Online Library
Abstract Aims Neurotrophins (NTs) have attracted considerable attention in the urologic
community. The reason for this resides in the recognition of their ability to induce plastic …
community. The reason for this resides in the recognition of their ability to induce plastic …