Antimicrobial dosing in the intensive care unit (ICU) can be problematic due to various
challenges including unique physiological changes observed in critically ill patients and the …

Population pharmacokinetics consists of analyzing pharmacokinetic (PK) data collected in
groups of individuals. Population PK is widely used to guide drug development and to inform …

Background Avibactam is a β-lactamase inhibitor that is combined with aztreonam against
Enterobacterales co-expressing serine-and metallo-β-lactamases (MBL). Optimal dosing of …

Continuous venovenous hemofiltration (CVVH) is a life‐sustaining procedure in patients
with severe burns and acute kidney injury. Physiologic changes from burn injury and use of …

Population pharmacokinetic (PK) modeling has become a cornerstone of drug development
and optimal patient dosing. This approach offers great benefits for datasets with sparse …

Background: Both parametric and nonparametric methods have been proposed to support
model-informed precision dosing (MIPD). However, which approach leads to better models …

Objective The objective of this study was to explore factors that affect the clearance of
imipenem in critically ill patients and to provide a dosing regimen for such patients. Methods …

Background Extracorporeal membrane oxygenation (ECMO), a cardiopulmonary bypass
device, has been found to increase the profound pathophysiological changes associated …

Background Sepsis is a life-threatening organ dysfunction caused by an excessive host
response to infection, manifested by elevated levels of inflammatory cytokines. At present …

Augmented renal clearance (ARC) can occur in critically ill pediatric patients receiving
aminoglycosides such as gentamicin and tobramycin, yet optimal dosing strategies for ARC …