Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a
significant burden on healthcare systems all over the world. The positive reinforcing …

Environmental stimuli are powerful mediators of craving and relapse in substance‐abuse
disorders. This review examined how animal models have been used to investigate the …

Positive social interactions are essential for emotional well-being and proper behavioral
development of young individuals. Here, we studied the neural underpinnings of social …

Social play behavior is a characteristic, vigorous form of social interaction in young
mammals. It is highly rewarding and thought to be of major importance for social and …

Sexual behavior of the male rat can be described as a 'sequence': a series of behavioral
transitions eventually leading to a consummatory act: ejaculation. A 'funnel-model'is …

Nicotine addiction is a major public health problem, resulting in primary glutamatergic
dysfunction. We measured the glutamate receptor binding in the human brain and provided …

Glutamate transmission is an important mediator of the development of substance use
disorders, particularly with regard to relapse. The present review summarizes the changes in …

Rationale Individuals vary considerably in the extent to which they attribute incentive
salience to food-associated cues. Objectives We asked whether individuals prone to …

Altered mesolimbic dopamine signaling has been widely implicated in addictive behavior.
For the most part, this work has focused on dopamine within the striatum, but there is …

Glutamatergic excitatory transmission is implicated in physiological and pathological
conditions like learning, memory, neuronal plasticity and emotions, while glutamatergic …