The dynamics of hematopoiesis over the human lifespan
Over a lifetime, hematopoietic stem cells (HSCs) adjust their lineage output to support age-
aligned physiology. In model organisms, stereotypic waves of hematopoiesis have been …
aligned physiology. In model organisms, stereotypic waves of hematopoiesis have been …
Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response
Somatic mutations in DNA methyltransferase 3A (DNMT3A) are among the most frequent
alterations in clonal hematopoiesis (CH) and acute myeloid leukemia (AML), with a hotspot …
alterations in clonal hematopoiesis (CH) and acute myeloid leukemia (AML), with a hotspot …
The super-enhancer-derived alncRNA-EC7/bloodlinc potentiates red blood cell development in trans
Enhancer-derived RNAs are thought to act locally by contributing to their parent enhancer
function. Whether large domains of clustered enhancers (super-enhancers) also produce cis …
function. Whether large domains of clustered enhancers (super-enhancers) also produce cis …
Targeted nanobubbles in low-frequency ultrasound-mediated gene transfection and growth inhibition of hepatocellular carcinoma cells
B Wu, Q Qiao, X Han, H **g, H Zhang, H Liang… - Tumor biology, 2016 - Springer
The use of SonoVue combined with ultrasound exposure increases the transfection
efficiency of short interfering RNA (siRNA). The objective of this study was to prepare …
efficiency of short interfering RNA (siRNA). The objective of this study was to prepare …
Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis
Folate, an essential vitamin, is a one-carbon acceptor and donor in key metabolic reactions.
Erythroid cells harbor a unique sensitivity to folate deprivation, as revealed by the primary …
Erythroid cells harbor a unique sensitivity to folate deprivation, as revealed by the primary …
Myeloid transformation by MLL-ENL depends strictly on C/EBP
R Wesolowski, E Kowenz-Leutz… - Life science …, 2021 - life-science-alliance.org
Chromosomal rearrangements of the mixed-lineage leukemia gene MLL1 are the hallmark
of infant acute leukemia. The granulocyte-macrophage progenitor state forms the epigenetic …
of infant acute leukemia. The granulocyte-macrophage progenitor state forms the epigenetic …
Nonspecific inhibition of erythropoiesis by short hairpin RNAs
EA Traxler, CS Thom, Y Yao… - Blood, The Journal of …, 2018 - ashpublications.org
10. Østgård LSG, Nørgaard M, Medeiros BC, et al. Effects of education and income on
treatment and outcome in patients with acute myeloid leukemia in a tax-supported health …
treatment and outcome in patients with acute myeloid leukemia in a tax-supported health …
CRISPR/Cas9-directed reassignment of the GATA1 initiation codon in K562 cells to recapitulate AML in Down syndrome
KM Bloh, PA Bialk, A Gopalakrishnapillai… - … therapy-Nucleic acids, 2017 - cell.com
Using a CRISPR/Cas9 system, we have reengineered a translational start site in the GATA1
gene in K562 cells. This mutation accounts largely for the onset of myeloid leukemia in …
gene in K562 cells. This mutation accounts largely for the onset of myeloid leukemia in …
[책][B] Establishing a consensus model for the role of genomic context in CRISPR-directed gene editing
KM Bloh Jr - 2022 - search.proquest.com
CRISPR-mediated gene editing systems have grown rapidly throughout all biological
disciplines, due to their ability to facilitate robust gene editing and its ease of use and …
disciplines, due to their ability to facilitate robust gene editing and its ease of use and …
[PDF][PDF] The Molecular Biology of Sickle Cell Anaemia
MF Shannon - 2017 - kclpure.kcl.ac.uk
Sickle cell anaemia (SCA) is a haemolytic anaemia that reduces life expectancy and places
a great burden on healthcare systems worldwide. Despite being a monogenic disorder, the …
a great burden on healthcare systems worldwide. Despite being a monogenic disorder, the …