Background Indiscriminate use of antibiotics leads to antibiotic resistance (AMR) and results
in mortality, morbidity, and financial burden. Antibiotic stewardship programs (ASPs) with …

Importance Hospital antimicrobial consumption data are widely available; however, large-
scale assessments of the quality of antimicrobial use in US hospitals are limited. Objective …

Background Children are the age group with the highest exposure to antibiotics (ABX). ABX
treatment changes the composition of the intestinal microbiota. The first few years of life are …

Background Antibiotic-associated adverse events (AEs) in hospitalized children have not
been comprehensively characterized. Methods We conducted a retrospective observational …

Background Antibiotics are prescribed to most pediatric intensive care unit (PICU) patients,
but data describing indications and appropriateness of antibiotic orders in this population …

Background Due to the high risk of severe infection among pediatric hematology and
oncology patients, antimicrobial use is particularly high. With our study, we quantitatively …

Introduction The most important and undesirable consequence of inappropriate antibiotic
use is the spread of antibiotic resistance, increased adverse effects, increased mortality and …

BACKGROUND Nearly 25% of antibiotics prescribed to children are inappropriate or
unnecessary, subjecting patients to avoidable adverse medication effects and cost …

Background Ciprofloxacin is a widely used antibiotic that has lost efficiency due to extensive
resistance. We developed machine learning (ML) models that predict the probability of …

Background Antimicrobial resistance is increasingly prevalent worldwide. The inappropriate
use of antimicrobials, including in the hospital setting, is considered a major driver of …