Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Abstract G-quadruplex (G4) structural motifs have been linked to transcription,, replication
and genome instability, and are implicated in cancer and other diseases,,. However, it is …

During genome replication, parental histones are recycled to newly replicated DNA with
their posttranslational modifications (PTMs). Whether sister chromatids inherit modified …

The establishment of cell identity during embryonic development involves the activation of
specific gene expression programmes and is underpinned by epigenetic factors including …

DNA replication is a tightly regulated process that ensures the precise duplication of the
genome during the cell cycle. In eukaryotes, the licensing and activation of replication …

The temporal order of DNA replication (replication timing [RT]) is highly coupled with
genome architecture, but cis-elements regulating either remain elusive. We created a series …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

Background DNA replication in mammalian cells occurs in a defined temporal order during
S phase, known as the replication timing (RT) programme. Replication timing is …