How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

The generation of organismal form—morphogenesis—arises from forces produced at the
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

Significant efforts have been directed to understanding the factors that influence the lineage
commitment of stem cells. This paper demonstrates that cell shape, independent of soluble …

Organ size is controlled by the concerted action of biochemical and physical processes.
Although mechanical forces are known to regulate cell and tissue behavior, as well as …

Many genes and molecules that drive tissue patterning during organogenesis and tissue
regeneration have been discovered. Yet, we still lack a full understanding of how these …

Embryonic morphogenesis requires the execution of complex mechanisms that regulate the
local behaviour of groups of cells. The orchestration of such mechanisms has been mainly …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …

Mechanotransduction research has focused historically on how externally applied forces
can affect cell signalling and function. A growing body of evidence suggests that contractile …

Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …