Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …

Trillions of intestinal bacteria in the human body undergo dynamic transformations in
response to physiological and pathological changes. Alterations in their composition and …

Imaging of both the positions and orientations of single fluorophores, termed single-
molecule orientation-localization microscopy, is a powerful tool for the study of biochemical …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …

Central to Alzheimer's disease (AD) is the assembly of the amyloid‐beta peptide (Aβ) into
fibrils. A reduction in pH accompanying inflammation or subcellular compartments, may …