The evolving story of apolipoprotein L1 nephropathy: the end of the beginning

P Daneshpajouhnejad, JB Kopp, CA Winkler… - Nature Reviews …, 2022 - nature.com
Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …

100 years of suramin

N Wiedemar, DA Hauser, P Mäser - Antimicrobial agents and …, 2020 - Am Soc Microbiol
Suramin is 100 years old and is still being used to treat the first stage of acute human
slee** sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

An update on African trypanocide pharmaceutics and resistance

KI Kasozi, ET MacLeod, I Ntulume… - Frontiers in Veterinary …, 2022 - frontiersin.org
African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense,
and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and …

Current treatments to control African trypanosomiasis and one health perspective

A Venturelli, L Tagliazucchi, C Lima, F Venuti… - Microorganisms, 2022 - mdpi.com
Human African Trypanosomiasis (HAT, slee** sickness) and Animal African
Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same …

Parasitic diseases of equids in Iran (1931–2020): a literature review

A Sazmand, A Bahari, S Papi, D Otranto - Parasites & vectors, 2020 - Springer
Parasitic infections can cause many respiratory, digestive and other diseases and contribute
to some performance conditions in equids. However, knowledge on the biodiversity of …

Salivarian trypanosomosis: a review of parasites involved, their global distribution and their interaction with the innate and adaptive mammalian host immune system

M Radwanska, N Vereecke, V Deleeuw… - Frontiers in …, 2018 - frontiersin.org
Salivarian trypanosomes are single cell extracellular parasites that cause infections in a
wide range of hosts. Most pathogenic infections worldwide are caused by one of four major …

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

RJ Wall, E Rico, I Lukac, F Zuccotto… - Proceedings of the …, 2018 - National Acad Sciences
African trypanosomes cause lethal and neglected tropical diseases, known as slee**
sickness in humans and nagana in animals. Current therapies are limited, but fortunately …

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing

EM Briggs, F Rojas, R McCulloch, KR Matthews… - Nature …, 2021 - nature.com
Developmental steps in the trypanosome life-cycle involve transition between replicative
and non-replicative forms specialised for survival in, and transmission between, mammalian …

The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets

F Altamura, R Rajesh, CMC Catta‐Preta… - Drug development …, 2022 - Wiley Online Library
Human trypanosomiasis and leishmaniasis are vector‐borne neglected tropical diseases
caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp …

Plant-based natural products for the discovery and development of novel anthelmintics against nematodes

M Liu, SK Panda, W Luyten - Biomolecules, 2020 - mdpi.com
Intestinal parasitic nematodes infect approximately two billion people worldwide. In the
absence of vaccines for human intestinal nematodes, control of infections currently relies …