Lithium induces autophagy by inhibiting inositol monophosphatase
Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins.
Currently, the only suitable pharmacologic strategy for up-regulating autophagy in …
Currently, the only suitable pharmacologic strategy for up-regulating autophagy in …
Inositol and human reproduction. From cellular metabolism to clinical use
EM Milewska, A Czyzyk, B Meczekalski… - Gynecological …, 2016 - Taylor & Francis
Inositol is an organic compound of high biological importance that is widely distributed in
nature. It belongs to the sugar family and is mainly represented by its two dominant …
nature. It belongs to the sugar family and is mainly represented by its two dominant …
[HTML][HTML] The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast
This article focuses on discoveries of the mechanisms governing the regulation of
glycerolipid metabolism and stress response signaling in response to the phospholipid …
glycerolipid metabolism and stress response signaling in response to the phospholipid …
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry
D Qiu, MS Wilson, VB Eisenbeis, RK Harmel… - Nature …, 2020 - nature.com
The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-
InsPs) is a daunting challenge due to the large number of possible isomers, the absence of …
InsPs) is a daunting challenge due to the large number of possible isomers, the absence of …
Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis
Y Hao, T Creson, L Zhang, P Li, F Du… - Journal of …, 2004 - Soc Neuroscience
Manic-depressive illness has been conceptualized as a neurochemical illness. However,
brain imaging and postmortem studies reveal gray-matter reductions, as well as neuronal …
brain imaging and postmortem studies reveal gray-matter reductions, as well as neuronal …
The Arabidopsis thaliana Myo-Inositol 1-Phosphate Synthase1 Gene Is Required for Myo-inositol Synthesis and Suppression of Cell Death
JL Donahue, SR Alford, J Torabinejad… - The Plant …, 2010 - academic.oup.com
Abstract l-myo-inositol 1-phosphate synthase (MIPS; EC 5.5. 1.4) catalyzes the rate-limiting
step in the synthesis of myo-inositol, a critical compound in the cell. Plants contain multiple …
step in the synthesis of myo-inositol, a critical compound in the cell. Plants contain multiple …
A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast
Cellular aging is a multifactorial process that is characterized by a decline in homeostatic
capacity, best described at the molecular level. Physicochemical properties such as pH and …
capacity, best described at the molecular level. Physicochemical properties such as pH and …
Valproate decreases inositol biosynthesis
G Shaltiel, A Shamir, J Shapiro, D Ding, E Dalton… - Biological …, 2004 - Elsevier
BACKGROUND: Lithium and valproate (VPA) are used for treating bipolar disorder. The
mechanism of mood stabilization has not been elucidated, but the role of inositol has gained …
mechanism of mood stabilization has not been elucidated, but the role of inositol has gained …
Inositol depletion, GSK3 inhibition and bipolar disorder
Valproic acid and lithium are widely used to treat bipolar disorder, a severe illness
characterized by cycles of mania and depression. However, their efficacy is limited, and …
characterized by cycles of mania and depression. However, their efficacy is limited, and …
New frontiers for the use of IP6 and inositol combination in treating diabetes mellitus: A review
FO Omoruyi, D Stennett, S Foster, L Dilworth - Molecules, 2020 - mdpi.com
Inositol, or myo-inositol, and associated analog molecules, including myo-inositol
hexakisphosphate, are known to possess beneficial biomedical properties and are now …
hexakisphosphate, are known to possess beneficial biomedical properties and are now …