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ENPP1, an old enzyme with new functions, and small molecule inhibitors—a STING in the tale of ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1) was identified several
decades ago as a type II transmembrane glycoprotein with nucleotide pyrophosphatase and …
decades ago as a type II transmembrane glycoprotein with nucleotide pyrophosphatase and …
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors
SY Lee, CE Müller - MedChemComm, 2017 - pubs.rsc.org
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1, EC 3.1. 4.1) is a
metalloenzyme that belongs to the NPP family, which comprises seven subtypes (NPP1-7) …
metalloenzyme that belongs to the NPP family, which comprises seven subtypes (NPP1-7) …
Discovery of Pyrido[2,3-d]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for …
Y Sun, M Chen, Y Han, W Li, X Ma, Z Shi… - Journal of Medicinal …, 2024 - ACS Publications
Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an extracellular enzyme
responsible for hydrolyzing cyclic guanosine monophosphate-adenosine monophosphate …
responsible for hydrolyzing cyclic guanosine monophosphate-adenosine monophosphate …
4H‐Pyrido[1,2‐a]pyrimidin‐4‐one, biologically important fused heterocyclic scaffold: Synthesis and functionalization
Abstract 4 H‐pyrido [1, 2‐a] pyrimidin‐4‐one and their derivatives are highly bioactive and
multipurpose heterocyclic motifs, having application in drugs, natural products …
multipurpose heterocyclic motifs, having application in drugs, natural products …
Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and-3 inhibitors
An extensive range of new biologically active morpholine based thiosemicarbazones
derivatives 3a-r were synthesized, characterized by spectral techniques and evaluated as …
derivatives 3a-r were synthesized, characterized by spectral techniques and evaluated as …
Insight into small-molecule inhibitors targeting extracellular nucleotide pyrophosphatase/phosphodiesterase1 for potential multiple human diseases
B Du, J Ru, Z Zhan, C Lin, Y Liu, W Mao… - European Journal of …, 2024 - Elsevier
Extracellular nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has been
identified as a type II transmembrane glycoprotein. It plays a crucial role in various biological …
identified as a type II transmembrane glycoprotein. It plays a crucial role in various biological …
[HTML][HTML] Development of novel ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors for tumor immunotherapy
X Wang, X Lu, D Yan, Y Zhou, X Tan - International Journal of Molecular …, 2022 - mdpi.com
The cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of
interferon genes–TANK-binding kinase 1–interferon regulating factor 3 (cGAS-STING-TBK1 …
interferon genes–TANK-binding kinase 1–interferon regulating factor 3 (cGAS-STING-TBK1 …
Structural basis for nucleotide recognition by the ectoenzyme CD 203c
A Gorelik, A Randriamihaja, K Illes… - The FEBS Journal, 2018 - Wiley Online Library
The ecto‐nucleotide pyrophosphatase/phosphodiesterase (NPP) enzyme family modulates
purinergic signaling by degrading extracellular nucleotides. CD 203c (NPP 3, ENPP 3) …
purinergic signaling by degrading extracellular nucleotides. CD 203c (NPP 3, ENPP 3) …
Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate …
In the present work we report the synthesis of new aryl pyrazole derivatives using 1, 3-
dicarbonyl motifs. The reaction was proceeded by the cyclization of pentane-2, 4-dione (1a) …
dicarbonyl motifs. The reaction was proceeded by the cyclization of pentane-2, 4-dione (1a) …
Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase …
A series of six compounds (1a-f) possessing pyridine-pyrazole-benzenethiourea or pyridine-
pyrazole-benzenesulfonamide scaffold were synthesized. The target compounds were …
pyrazole-benzenesulfonamide scaffold were synthesized. The target compounds were …