Benzothiazole‐based apoptosis inducers: A comprehensive overview and future prospective

P Kamboj, A Mahore, A Husain, M Amir - Archiv der Pharmazie, 2024 - Wiley Online Library
Cancer has become a major concern in healthcare globally, and over time, incidences and
prevalence of cancer are increasing. To counter this, a lot of anticancer drugs are approved …

Oncogenic BRAF and p53 interplay in melanoma cells and the effects of the HDAC inhibitor ITF2357 (Givinostat)

A Celesia, M Franzò, D Di Liberto, M Lauricella… - International Journal of …, 2023 - mdpi.com
Oncogenic BRAF mutations have been widely described in melanomas and promote tumour
progression and chemoresistance. We previously provided evidence that the HDAC inhibitor …

[HTML][HTML] Liposomal formulations of a new zinc (II) complex exhibiting high therapeutic potential in a murine colon cancer model

N Ribeiro, M Albino, A Ferreira, C Escrevente… - International Journal of …, 2022 - mdpi.com
Colorectal cancer is the second leading cause of cancer-related mortality. Many current
therapies rely on chemotherapeutic agents with poor specificity for tumor cells. The clinical …

MAPK14 (p38α) inhibition effects against metastatic gastric cancer cells: A potential biomarker and pharmacological target

FP Mesquita, CA Moreira-Nunes, EL da Silva, LB Lima… - Toxicology in Vitro, 2020 - Elsevier
Gastric cancer has been considering one of the worst cancer types since it is diagnosed in
advanced stages, currently in the metastatic stage. Therefore, the challenge is to find out a …

Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death

EL da Silva, FP Mesquita, DR Aragão… - Toxicology and Applied …, 2023 - Elsevier
Gastric cancer (GC) is among the most-diagnosed and deadly malignancies worldwide.
Deregulation in cellular bioenergetics is a hallmark of cancer. Based on the importance of …

[HTML][HTML] Lignin nanoparticles deliver novel thymine biomimetic photo-adducts with antimelanoma activity

S Gabellone, D Piccinino, S Filippi… - International Journal of …, 2022 - mdpi.com
We report here the synthesis of novel thymine biomimetic photo-adducts bearing an alkane
spacer between nucleobases and characterized by antimelanoma activity against two …

Anticancer potential of corilagin on T24 and TSGH 8301 bladder cancer cells via the activation of apoptosis by the suppression of NF‐κB‐induced P13K/Akt signaling …

X Yu, T Wu, B Liao, Z Du, P Zhu - Environmental Toxicology, 2022 - Wiley Online Library
Bladder cancer (BC) is a primary source of malignancy‐associated death, and the mortality
rate is high due to its prevalence of metastasis. Corilagin (CLG), a bioactive constituent of …

Inhibiting the PI3K/Akt, NF‐κB signalling pathways with syringic acid for attenuating the development of oral squamous cell carcinoma cells SCC131

P Velu, A Vijayalakshmi… - Journal of Pharmacy and …, 2020 - Wiley Online Library
Objectives To evaluate the anti‐inflammatory and antiproliferative effect of syringic acid
(SRA) on oral squamous cell carcinoma (OSCC) SCC131 cells via suppression of NF‐κB …

Differences in glucose concentration shows new perspectives in gastric cancer metabolism

EL da Silva, FP Mesquita, AJ de Sousa Portilho… - Toxicology in Vitro, 2022 - Elsevier
Gastric cancer (GC) is among the deadliest cancers worldwide despite available therapies,
highlighting the need for novel therapies and pharmacological agents. Metabolic …

Small benzothiazole molecule induces apoptosis and prevents metastasis through DNA interaction and c-MYC gene supression in diffuse-type gastric …

FP Mesquita, LC Pinto, BM Soares… - Chemico-Biological …, 2018 - Elsevier
Chemo-resistance has been reported as a relevant barrier for the efficiency of gastric cancer
treatment. Therefore, the development of effective and safe drugs for cancer chemotherapy …