Transient receptor potential cation channels in disease
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
A Szallasi, DN Cortright, CA Blum, SR Eid - Nature reviews Drug …, 2007 - nature.com
The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
Capsaicin, nociception and pain
B Frias, A Merighi - Molecules, 2016 - mdpi.com
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …
Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions
YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
[HTML][HTML] TRP channels in cancer
N Prevarskaya, L Zhang, G Barritt - … Acta (BBA)-Molecular Basis of Disease, 2007 - Elsevier
The progression of cells from a normal differentiated state in which rates of proliferation and
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …
Autoimmune diseases and polyamines
WH Brooks - Clinical reviews in allergy & immunology, 2012 - Springer
Genetics and environmental factors have important roles in autoimmune diseases but
neither has given us sufficient understanding of these mysterious diseases. Therefore, we …
neither has given us sufficient understanding of these mysterious diseases. Therefore, we …
[HTML][HTML] Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
P Holzer - Pharmacology & therapeutics, 2011 - Elsevier
Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …
are expressed by specific neurons and cells within the alimentary canal. They subserve …
Polyamines control of cation transport across plant membranes: implications for ion homeostasis and abiotic stress signaling
Polyamines are unique polycationic metabolites, controlling a variety of vital functions in
plants, including growth and stress responses. Over the last two decades a bulk of data was …
plants, including growth and stress responses. Over the last two decades a bulk of data was …
TRPV1 shows dynamic ionic selectivity during agonist stimulation
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious
heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers …
heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers …
Modulation of TRPV1 channel function by natural products in the treatment of pain
MA Abbas - Chemico-biological interactions, 2020 - Elsevier
The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …