Pathogenesis of celiac disease and other gluten related disorders in wheat and strategies for mitigating them

N Sharma, S Bhatia, V Chunduri, S Kaur… - Frontiers in …, 2020 - frontiersin.org
Wheat is a major cereal crop providing energy and nutrients to the billions of people around
the world. Gluten is a structural protein in wheat, that is necessary for its dough making …

Plant genome engineering for targeted improvement of crop traits

KEM Sedeek, A Mahas, M Mahfouz - Frontiers in plant science, 2019 - frontiersin.org
To improve food security, plant biology research aims to improve crop yield and tolerance to
biotic and abiotic stress, as well as increasing the nutrient contents of food. Conventional …

Low‐gluten, nontransgenic wheat engineered with CRISPR/Cas9

S Sánchez‐León, J Gil‐Humanes… - Plant biotechnology …, 2018 - Wiley Online Library
Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals
by the ingestion of gluten proteins from wheat, barley and rye. The α‐gliadin gene family of …

What is gluten—why is it special?

P Shewry - Frontiers in nutrition, 2019 - frontiersin.org
Wheat gluten has an immense impact on human nutrition as it largely determines the
processing properties of wheat flour, and in particular the ability to make leavened breads …

Gluten-free bakery and pasta products: prevalence and quality improvement

Y Gao, ME Janes, B Chaiya, MA Brennan… - … Journal of Food …, 2018 - academic.oup.com
An increasing demand of gluten-free (GF) products is caused by a growing number of
diagnosed coeliacs and a consumption trend to eliminate allergenic proteins from diet …

Nutritionally enhanced food crops; progress and perspectives

KL Hefferon - International journal of molecular sciences, 2015 - mdpi.com
Great progress has been made over the past decade with respect to the application of
biotechnology to generate nutritionally improved food crops. Biofortified staple crops such as …

CRISPR/Cas9 gene editing of gluten in wheat to reduce gluten content and exposure—Reviewing methods to screen for coeliac safety

A Jouanin, LJWJ Gilissen, JG Schaart, FJ Leigh… - Frontiers in …, 2020 - frontiersin.org
Ingestion of gluten proteins (gliadins and glutenins) from wheat, barley and rye can cause
coeliac disease (CD) in genetically predisposed individuals. The only remedy is a strict and …

Genomics as the key to unlocking the polyploid potential of wheat

P Borrill, N Adamski, C Uauy - New Phytologist, 2015 - Wiley Online Library
Polyploidy has played a central role in plant genome evolution and in the formation of new
species such as tetraploid pasta wheat and hexaploid bread wheat. Until recently, the high …

CRISPR/Cas9-mediated multiplex gene editing of gamma and omega gliadins: paving the way for gliadin-free wheat

S Sánchez-León, M Marín-Sanz… - Journal of …, 2024 - academic.oup.com
Wheat is a staple cereal in the human diet. Despite its significance, an increasing
percentage of the population suffers adverse reactions to wheat, which are triggered by …

An elite γ‐gliadin allele improves end‐use quality in wheat

D Liu, H Yang, Z Zhang, Q Chen, W Guo… - New …, 2023 - Wiley Online Library
Gluten is composed of glutenins and gliadins and determines the viscoelastic properties of
dough and end‐use quality in wheat (Triticum aestivum L.). Gliadins are important for wheat …