Exciting new technologies are often self-limiting in their rollout, as access to state-of-the-art
instrumentation or the need for years of hands-on experience, for better or worse, ensures …

Human genetics research has discovered thousands of proteins associated with complex
and rare diseases. Genome-wide association studies (GWAS) and studies of Mendelian …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the curation and archival …

CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across
large panels of cell lines to identify new therapeutic targets for precision cancer therapy …

In recent years, CRISPR–Cas9 technology is widely acknowledged for having major
applications in the field of biotechnology for editing genome of any organism to treat a …

High-throughput genetic screens interfering with gene expression are invaluable tools to
identify gene function and phenotype-to-genotype interactions. Implementing such screens …

CRISPR–Cas9 screens have emerged as a transformative approach to systematically probe
gene functions. The quality and success of these screens depends on the frequencies of …

CRISPR genetic screens in cancer cell models are a powerful tool to elucidate oncogenic
mechanisms and to identify promising therapeutic targets. The Project Score database …

Pooled CRISPR screens are a powerful tool for assessments of gene function. However,
conventional analysis is based exclusively on the relative abundance of integrated single …

Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats and
CRISPR-associated protein 9) is a popular and effective two-component technology used for …