Cancer is a problem with worldwide importance and is the second leading cause of death
globally. Cancer cells reprogram their metabolism to support their uncontrolled expansion …

During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

Background Electronic nicotine-delivery systems—also called e-cigarettes—are used by
some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Buccal swabs and saliva are the two most common oral sampling methods used for medical
research. Often, these samples are used interchangeably, despite previous evidence that …

Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and
chromosomal instability in humans. They originate from chromosome fragments or intact …

The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used
techniques to measure genetic damage in human population studies. Reducing protocol …

Accumulation of deoxyribonucleic acid (DNA) damage diminishes cellular health, increases
risk of developmental and degenerative diseases, and accelerates aging. Optimizing …

The buccal micronucleus cytome assay is a minimally invasive cytological and interphase
cytogenetic technique for measuring DNA damage and cell death biomarkers in the oral …

The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …