Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

BACKGROUND In adult mammalian organisms, multiple tissues—including the skin, blood,
stomach, and intestines—are entrapped in a state of permanent regeneration; older cells are …

Programmed cell death (PCD) plays a fundamental role in animal development and tissue
homeostasis. Abnormal regulation of this process is associated with a wide variety of human …

Human bodies collectively turn over about 200 billion to 300 billion cells every day. Such
turnover is an integral part of embryonic and postnatal development, as well as routine …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

In cancer treatment, apoptosis is a well-recognized cell death mechanism through which
cytotoxic agents kill tumor cells. Here we report that dying tumor cells use the apoptotic …

The ability of animals to regenerate missing parts is a dramatic and poorly understood
aspect of biology. The sources of new cells for these regenerative phenomena have been …

Extracellular vesicles (EVs) derived from living cells play important roles in donor cell-
induced recipient tissue regeneration. Although numerous studies have found that cells …