Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases
S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …
challenges to public health security and the global economy. The development and …
Interferon-λ orchestrates innate and adaptive mucosal immune responses
Type III interferon (IFN-λ) was initially thought to have functions similar to those of the type I
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …
Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates
Dear Editor, Omicron (B. 1.1. 529), is a heavily mutated and highly contagious SARS-CoV-2
variant, which is currently causing large outbreaks in many countries. Protection provided by …
variant, which is currently causing large outbreaks in many countries. Protection provided by …
[HTML][HTML] SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon
M Shemesh, TE Aktepe, JM Deerain, JL McAuley… - PLoS …, 2021 - journals.plos.org
Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …
[HTML][HTML] SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant
Y Konno, I Kimura, K Uriu, M Fukushi, T Irie… - Cell reports, 2020 - cell.com
One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
[HTML][HTML] Imbalanced host response to SARS-CoV-2 drives development of COVID-19
Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to
humanity. Because of its recent emergence, there is a paucity of information regarding viral …
humanity. Because of its recent emergence, there is a paucity of information regarding viral …
SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems
One of the greatest threats to humanity is the emergence of a pandemic virus. Among those
with the greatest potential for such an event include influenza viruses and coronaviruses. In …
with the greatest potential for such an event include influenza viruses and coronaviruses. In …
[HTML][HTML] TMEM41B is a pan-flavivirus host factor
HH Hoffmann, WM Schneider, K Rozen-Gagnon… - Cell, 2021 - cell.com
Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …
[HTML][HTML] Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection
Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while
minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying …
minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying …
[HTML][HTML] RIG-I in RNA virus recognition
Antiviral immunity is initiated upon host recognition of viral products via non-self molecular
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …