Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

Mitophagy, the selective degradation of mitochondria, is impaired in many
neurodegenerative diseases (NDs), resulting in an accumulation of dysfunctional …

The interplay between socio-psychological factors and biological systems is pivotal in
defining human health and disease, particularly in chronic non-communicable diseases …

The sub-compartmentalization of cellular processes is especially important in highly
polarized cells such as neurons, as their function rely on their complex morphology. The …

Calcium signaling plays a pivotal role in diverse cellular processes through precise
spatiotemporal regulation and interaction with effector proteins across distinct subcellular …

Simple Summary Mitochondria-sha** proteins are pivotal in maintaining the dynamic
structure of mitochondria, which constantly undergo fusion and fission. This dynamic …

A central role in mitochondrial quality control is played by the Parkinson-related
mitochondrial kinase PINK1, whose mRNA is transported in neurons by mitochondrial hitch …

Alzheimer's disease (AD) is an incurable and progressive neurodegenerative disease with
increasing prevalence worldwide. Previous trials of anti-amyloid and anti-tau …

Mitochondria are often referred to as the “powerhouse” of the cell. However, this organelle
has many more functions than simply satisfying the cells' metabolic needs. Mitochondria are …

Insulin signaling is crucial for maintaining cellular function and systemic homeostasis, with
its dysregulation leading to metabolic disorders in particular diabetes. While insulin analogs …