The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that
purpose, has garnered marked interest over the past two decades as an emerging treatment …

Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …

Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened
latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram …

Sleep disturbances and depression are closely linked and share a bidirectional relationship.
These interconnections can inform the pathophysiology underlying each condition. Insomnia …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Sleep disturbances and suicidal behaviour are highly prevalent phenomena, representing
with a significant burden to society. Sleep has been acknowledged as a potential biomarker …