Biological materials found in living organisms, many of which are proteins, feature a
complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in …

Most tissues of the human body present hierarchical fibrillar extracellular matrices (ECMs)
that have a strong influence over their physicochemical properties and biological behavior …

Collagen (Col) hydrogels have poor physicochemical and mechanical properties and are
susceptible to substantial shrinkage during cell culture, which limits their potential …

While matrix stiffness has been implicated in cell adhesion and migration, most studies have
focused on the effects of substrate stiffness in 2D. The present work describes a novel …

There has been a drive to develop new cell based therapies to treat corneal blindness, one
of the most common causes of blindness worldwide. Mechanical and physical cues are …

Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts
are in short supply, and can be associated with pain and donor-site morbidity. The creation …

It is likely that mesenchymal stem cells will find use in many autologous regenerative
therapies. However, our ability to control cell stem growth and differentiation is presently …

The proteoglycan decorin is known to affect both the fibrillogenesis and the resulting
ultrastructure of in vitro polymerized collagen gels. However, little is known about its effects …

Tendons are force transmitting mechanosensitive tissues predominantly comprised of highly
aligned collagen type I fibres. In this study, the recently introduced gel aspiration-ejection …

The extracellular matrix (ECM) has force‐responsive (ie, mechanochemical) properties that
enable adaptation to mechanical loading through changes in fibrous network structure and …