Molecular and cellular mechanisms of liver fibrosis and its regression

T Kisseleva, D Brenner - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes

A Asai, A Miethke, JA Bezerra - Nature reviews Gastroenterology & …, 2015 - nature.com
Biliary atresia is a severe cholangiopathy of early infancy that destroys extrahepatic bile
ducts and disrupts bile flow. With a poorly defined disease pathogenesis, treatment consists …

Guideline for the evaluation of cholestatic jaundice in infants: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and …

R Fawaz, U Baumann, U Ekong… - Journal of pediatric …, 2017 - journals.lww.com
Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is
infrequently recognized by primary providers in the setting of physiologic jaundice …

[PDF][PDF] Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care

SS Sundaram, CL Mack, AG Feldman… - Liver …, 2017 - Wiley Online Library
Biliary atresia (BA) is a progressive, fibro‐obliterative disorder of the intrahepatic and
extrahepatic bile ducts in infancy. The majority of affected children will eventually develop …

Impact of age at Kasai operation on its results in late childhood and adolescence: a rational basis for biliary atresia screening

MO Serinet, BE Wildhaber, P Broue, A Lachaux… - …, 2009 - publications.aap.org
BACKGROUND. Increased age at surgery has a negative impact on results of the Kasai
operation for biliary atresia in infancy and early childhood. It remained unclear if an age …

Diagnostic yield of newborn screening for biliary atresia using direct or conjugated bilirubin measurements

S Harpavat, JA Garcia-Prats, C Anaya, ML Brandt… - Jama, 2020 - jamanetwork.com
Importance Treating biliary atresia in newborns earlier can delay or prevent the need for
liver transplant; however, treatment typically occurs later because biliary atresia is difficult to …

[PDF][PDF] Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the American Association for the Study of Liver Diseases, American …

RH Squires, V Ng, R Romero, U Ekong… - …, 2014 - Wiley Online Library
Each Association appointed at least one author to serve on the writing group. The Chair of
the writing group was appointed by the AASLD. Members of the writing group were not …

Biliary atresia in England and Wales: results of centralization and new benchmark

M Davenport, E Ong, K Sharif, N Alizai… - Journal of pediatric …, 2011 - Elsevier
INTRODUCTION: Biliary atresia (BA) is a rare, potentially life-threatening condition of the
newborn presenting with conjugated jaundice. Typically, it is treated by an initial attempt to …

Improving outcomes of biliary atresia: French national series 1986–2009

C Chardot, C Buet, MO Serinet, JL Golmard… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: This study analyses the prognosis of biliary atresia (BA) in France
since liver transplantation (LT) became widely available. METHODS: The charts of all BA …

Biliary atresia and other cholestatic childhood diseases: advances and future challenges

HJ Verkade, JA Bezerra, M Davenport… - Journal of …, 2016 - Elsevier
Biliary Atresia and other cholestatic childhood diseases are rare conditions affecting the
function and/or anatomy along the canalicular-bile duct continuum, characterised by onset of …