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Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
Fighting age-related orthopedic diseases: focusing on ferroptosis
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
Polydopamine nanoparticles targeting ferroptosis mitigate intervertebral disc degeneration via reactive oxygen species depletion, iron ions chelation, and GPX4 …
X Yang, Y Chen, J Guo, J Li, P Zhang… - Advanced …, 2023 - Wiley Online Library
Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common
problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based …
problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based …
[HTML][HTML] Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor
Y Zhao, H Zhang, JG Cui, JX Wang, MS Chen… - Redox biology, 2023 - Elsevier
The global rate of human male infertility is rising at an alarming rate owing to environmental
and lifestyle changes. Phthalates are the most hazardous chemical additives in plastics and …
and lifestyle changes. Phthalates are the most hazardous chemical additives in plastics and …
[HTML][HTML] The role of oxidative stress in skeletal muscle myogenesis and muscle disease
The contractile activity, high oxygen consumption and metabolic rate of skeletal muscle
cause it to continuously produce moderate levels of oxidant species, such as reactive …
cause it to continuously produce moderate levels of oxidant species, such as reactive …
The road from AKI to CKD: molecular mechanisms and therapeutic targets of ferroptosis
R Guo, J Duan, S Pan, F Cheng, Y Qiao, Q Feng… - Cell death & …, 2023 - nature.com
Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a
precipitous decline in renal function. In recent years, a growing body of studies have …
precipitous decline in renal function. In recent years, a growing body of studies have …
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is caused by selective degeneration of motor neurons in
the brain and spinal cord; however, the primary cell death pathway (s) mediating motor …
the brain and spinal cord; however, the primary cell death pathway (s) mediating motor …
Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids
P Yang, J Li, T Zhang, Y Ren, Q Zhang, R Liu… - Cell Death & …, 2023 - nature.com
Ferroptosis is a type of cell death characterized by the accumulation of intracellular iron and
an increase in hazardous lipid peroxides. Ferroptosis and autophagy are closely related …
an increase in hazardous lipid peroxides. Ferroptosis and autophagy are closely related …
FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC
R Li, X Yan, C **ao, T Wang, X Li, Z Hu, J Liang… - Nature …, 2024 - nature.com
Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely
limits their utilization in liver transplantation. The potential mechanism remains unclear …
limits their utilization in liver transplantation. The potential mechanism remains unclear …