SLC transporters as therapeutic targets: emerging opportunities
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …
facilitate the transport of a wide array of substrates across biological membranes—have …
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential
Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …
treatment, is a major health problem impacting the quality of life and producing a significant …
The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain
SEI Van Der Wal, SAS Van Den Heuvel… - … journal of pain, 2016 - Wiley Online Library
Introduction The neuroinflammatory response plays a key role in several pain syndromes.
Intravenous (iv) lidocaine is beneficial in acute and chronic pain. This review delineates the …
Intravenous (iv) lidocaine is beneficial in acute and chronic pain. This review delineates the …
Allosteric modulation of neurotransmitter transporters as a therapeutic strategy
Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …
Advances in D-amino acids in neurological research
JM Seckler, SJ Lewis - International journal of molecular sciences, 2020 - mdpi.com
D-amino acids have been known to exist in the human brain for nearly 40 years, and they
continue to be a field of active study to today. This review article aims to give a concise …
continue to be a field of active study to today. This review article aims to give a concise …
Glycine receptors and glycine transporters: targets for novel analgesics?
Glycinergic neurotransmission has long been known for its role in spinal motor control.
During the last two decades, additional functions have become increasingly recognized …
During the last two decades, additional functions have become increasingly recognized …
Presynaptic glutamate receptors in nociception
RG ** review of current literature
C Fenech, BL Winters, Y Otsu… - Journal of …, 2024 - Wiley Online Library
The neurotransmitter glycine is an agonist at the strychnine‐sensitive glycine receptors. In
addition, it has recently been discovered to act at two new receptors, the excitatory glycine …
addition, it has recently been discovered to act at two new receptors, the excitatory glycine …
Heteromeric solute carriers: function, structure, pathology and pharmacology
SJ Fairweather, N Shah, S Brӧer - Protein Reviews: Volume 21, 2021 - Springer
Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …
and include uniporters, exchangers and symporters. Following several decades of …
Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes
Q Cheng, N Shah, A Bröer… - British journal of …, 2017 - Wiley Online Library
Background and Purpose The neutral amino acid transporter B0AT1 (SLC6A19) has
recently been identified as a possible target to treat type 2 diabetes and related disorders …
recently been identified as a possible target to treat type 2 diabetes and related disorders …