Chlorogenic acid: A systematic review on the biological functions, mechanistic actions, and therapeutic potentials
Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in
many plants such as green coffee beans. As an active natural substance, CGA exerts …
many plants such as green coffee beans. As an active natural substance, CGA exerts …
Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …
Busting the myth of methotrexate chronic hepatotoxicity
Methotrexate is a key component of the treatment of inflammatory rheumatic diseases and
the mainstay of therapy in rheumatoid arthritis. Hepatotoxicity has long been a concern for …
the mainstay of therapy in rheumatoid arthritis. Hepatotoxicity has long been a concern for …
[HTML][HTML] Pharmacological effects of polyphenol phytochemicals on the intestinal inflammation via targeting TLR4/NF-κB signaling pathway
C Yu, D Wang, Z Yang, T Wang - International journal of molecular …, 2022 - mdpi.com
TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell
differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 …
differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 …
Chlorogenic acid improves health in juvenile largemouth bass (Micropterus salmoides) fed high-fat diets: Involvement of lipid metabolism, antioxidant ability …
High-fat diets (HFD) is widely applied in aquaculture to achieve a protein-saving effect,
whereas long-term intake of high-fat feed will negatively affect the health of fish. Chlorogenic …
whereas long-term intake of high-fat feed will negatively affect the health of fish. Chlorogenic …
[HTML][HTML] Diosmin alleviates doxorubicin-induced liver injury via modulation of oxidative stress-mediated hepatic inflammation and apoptosis via NfkB and MAPK …
Hepatotoxicity caused by chemotherapeutic drugs (eg, doxorubicin) is of critical concern in
cancer therapy. This study focused on investigating the modulatory effects of diosmin …
cancer therapy. This study focused on investigating the modulatory effects of diosmin …
Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats
Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is
one of the most effective natural supplements available; however, its ameliorative …
one of the most effective natural supplements available; however, its ameliorative …
Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects
H Xue, M Wei, L Ji - Phytomedicine, 2023 - Elsevier
Background Liver diseases have a negative impact on global health and are a leading
cause of death worldwide. Chlorogenic acids (CGAs), a family of esters formed between …
cause of death worldwide. Chlorogenic acids (CGAs), a family of esters formed between …
Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury in mice by synergistic antioxidant effects
Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the
treatment of different types of cancers and the management of chronic inflammatory …
treatment of different types of cancers and the management of chronic inflammatory …
[HTML][HTML] Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats
Hepatotoxicity is one of the major side effects of methotrexate (MTX), which restricts the
clinical use of this drug. Berberine (BBR) is a natural compound with multiple …
clinical use of this drug. Berberine (BBR) is a natural compound with multiple …