Synthesis, biological evaluation and DFT calculation of novel pyrazole and pyrimidine derivatives

AM Farag, AM Fahim - Journal of Molecular Structure, 2019 - Elsevier
The utility of the enaminonitriles 3a and 3b for the synthesis of the pyrazole derivatives 5a, b,
7a, b, diaminopyrimidine derivatives 9, 11, pyrazolo [1, 5-a] pyrimidines 12, 15, triazolo [4, 3 …

[HTML][HTML] Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity

ME Salem, IA Abdelhamid, AHM Elwahy, MA Ragheb… - Heliyon, 2024 - cell.com
The reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-
thiosemicarbazones, or 4-amino-3-mercapto-1, 2, 4-triazole in dioxane in the presence of …

Utility of 2-Chloro-N-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]

ME Salem, AH Abdullah, MEA Zaki, IA Abdelhamid… - ACS …, 2024 - ACS Publications
A series of novel thieno [2, 3-b] pyridines linked to N-aryl carboxamides or
(carbonylphenoxy)-N-(aryl) acetamides, as well as bis (thieno [2, 3-b] pyridines) linked to …

Medicinal chemistry of pyrazolopyrimidine scaffolds substituted with different heterocyclic nuclei

GH Elgemeie, RA Azzam, WA Zaghary… - Current …, 2022 - benthamdirect.com
Background: Medicinal chemistry of pyrazolopyrimidine scaffolds substituted with different
heterocyclic nuclei has attracted great attention due to their wide range of biological …

[HTML][HTML] Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems

HM Diab, IA Abdelhamid, ME Salem, I Ragab… - Results in …, 2024 - Elsevier
Synthesis of analogs of known active compounds is the most often employed strategy for
producing important compounds. The Hantzsch reaction was employed to create new star …

Synthesis and DFT calculations of aza-Michael adducts obtained from degradation poly (methyl methacrylate) plastic wastes

AM Fahim, AM Farag, GAM Nawwar… - International …, 2019 - inderscienceonline.com
Aza-Michael adducts are obtained in excellent yields by the conjugate addition of
nucleophilic reagents with α, β-unsaturated substrates such as methyl methacrylate (MMA) …

[PDF][PDF] Novel bis ([triazolo [3, 4-b] thiadiazoles and bis ([triazolo [3, 4-b][thiadiazines) with antioxidant activity

AHM Elwahy, ARS Ginidi, MR Shaaban… - Arkivoc, 2024 - pdfs.semanticscholar.org
A novel bis-triazole was synthesized in this context, and its potential usage as a flexible
precursor for new bistriazolothiadiazines and bis-triazolothiadiazoles with antioxidant …

Regioselective synthesis and DFT study of novel fused heterocyclic utilizing Thermal heating and Microwave Irradiation

AM Fahim, AM Farag, MR Shaaban, EA Rabag - Afinidad, 2018 - raco.cat
Regioselective facile synthesis of innovative heterocycles from the reaction of 2-cyano-N-
cyclohexylacetamide (3) with N, N-dimethylformamide dimethylacetal (DMF-DMA) to afford …

[PDF][PDF] Microwave assisted regioselective synthesis and biological evaluation of pyrano [2, 3-c] pyridine derivatives utilizing DMAP as a catalyst

AM Fahim - Online J. Biol. Sci., 2017 - academia.edu
Regioselective facile production of pyrano [2, 3-c] pyridine through multicomponent reaction
of aromatic aldehydes, ethyl cyano acetate or malononitrile and CH activated compound of 3 …

Decoding the reaction mechanism of the cyclocondensation of ethyl acetate2‐oxo‐2‐(4‐oxo‐4H‐pyrido [1.2‐a] pyrimidin‐3‐yl) polyazaheterocycle and …

MB Maraf, AA Idrice… - Journal of …, 2022 - Wiley Online Library
We investigated the flow of electron density along the cyclocondensation reaction between
ethyl acetate 2‐oxo‐2‐(4‐oxo‐4 H‐pyrido [1.2‐a] pyrimidin‐3‐yl) polyazaheterocycle (1) …