LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

Two facts about the hippocampus have been common currency among neuroscientists for
several decades. First, lesions of the hippocampus in humans prevent the acquisition of new …

While deep learning has led to remarkable advances across diverse applications, it
struggles in domains where the data distribution changes over the course of learning. In …

The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

Recent findings of spike timing-dependent plasticity (STDP) have stimulated much interest
among experimentalists and theorists. Beyond the traditional correlation-based Hebbian …

Summary Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological
disorders, but its role in normal neuronal function is largely unknown. Here we show that …

Silent synapses abound in the young brain, representing an early step in the pathway of
experience-dependent synaptic development. Discovered amidst the debate over whether …

Information in the nervous system may be carried by both the rate and timing of neuronal
spikes. Recent findings of spike timing-dependent plasticity (STDP) have fueled the interest …

Synapses are crucial structures that mediate signal transmission between neurons in
complex neural circuits and display considerable morphological and electrophysiological …

Beyond their well-established role as triggers for LTP and LTD of fast synaptic transmission
mediated by AMPA receptors, an expanding body of evidence indicates that NMDA …