Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Animal models of adult-onset neurodegenerative diseases have enhanced the
understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease …

Parkinson's disease (PD) is the most common movement disorder with motor and nonmotor
signs. The current therapeutic regimen for PD is mainly symptomatic as the etio …

The last decade has been marked by tremendous progress in our understanding of the cell
biology of mitochondria, with the identification of molecules and mechanisms that regulate …

Autophagy is a major intracellular degradative process that delivers cytoplasmic materials to
the lysosome for degradation. Since the discovery of autophagy-related (Atg) genes in the …

Parkinson disease (PD) is a complex neurodegenerative disorder with both motor and
nonmotor symptoms owing to a spreading process of neuronal loss in the brain. At present …

Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …

Recent investigation into the mechanisms of Parkinson's disease (PD) has generated
remarkable insight while simultaneously challenging traditional conceptual frameworks …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …